Investigador Principal | Responsable del Módulo de Biopsia Líquida

Sara López-Tarruella

MD, PhD, Hospital Universitario X

Biografía y Trayectoria

Sara works as an attending physician at the Medical Oncology Service of Hospital General Universitario Gregorio Marañon (Madrid). She focuses her research on one hand on breast cancer prevention and treatment, especially in the triple negative subtype, the neoadjuvant model and early-phase new drug development, and on the other hand on translational research, PDX models and the liquid biopsy. After specializing in Medical Oncology in 2006, she began her fellowship in translational research at Baylor College of Medicine in the Breast Center (Houston) based on the molecular mechanisms of breast cancer resistance to endocrine therapy. Then, in 2009, Dr. López-Tarruella obtained her PhD degree at Universidad Complutense (Madrid), studying de novo metastatic breast cancer prognostic factors in the GEICAM Alamo project I-II. Dr. López-Tarruella currently works as Physician Assistant in the breast cancer and phase I trial units at HGUGM, contributing as co-investigator in several clinical and translational research trials. Since 2007, she has been principal and sub-investigator in more than 50 phase I-III clinical trials and observational studies. She is full member of scientific societies and research cooperative groups (GEICAM, SEOM and ESMO), as well as Associate Professor at the Universidad Complutense de Madrid (Medicine Department). She has published more than 50 research papers in indexed journals (H-Index= 19).

Líneas de Investigación Actuales

  • Optimización de protocolos de aislamiento de ctDNA.
  • Evaluación del valor pronóstico de las Células Tumorales Circulantes (CTCs).
  • Desarrollo de paneles de secuenciación de nueva generación (NGS) adaptados a la biopsia líquida.
  • Estudio de microvesículas y exosomas en la metástasis tumoral.

Publicaciones Destacadas

Puede consultar el listado completo en el perfil ORCID.

El Dr. Toledo ha publicado más de 50 artículos en revistas peer-reviewed, incluyendo *JAMA Oncology* y *Clinical Cancer Research*. Es revisor habitual de diversas revistas científicas internacionales y participa activamente en congresos internacionales.